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HIVINNOV (Grant n°305137) is a collaborative research project supported by the European Union



Heat shock protein 90 controls HIV-1 reactivation from latency


Anderson I, Low JS, Weston S, Weinberger M, Zhyvoloup A, Labokha AA, Corazza G, Kitson RA, Moody CJ, Marcello A, Fassati A.

PNAS (2014) Apr 15;111(15):E1528-37

PMID : 24706778


Structural basis for nuclear import of splicing factors by human Transportin 3


Goedele N. Maertens, Nicola J. Cook, Weifeng Wang, Stephen Hare, Saumya Shree Gupta, Ilker Öztop,KyeongEun Lee, Valerie E. Pye, Ophélie Cosnefroy, Ambrosius P. Snijders, Vineet N. KewalRamani, Ariberto Fassati, Alan Engelman and Peter Cherepanov

PNAS 2014 Feb 18;111(7):2728-33

PMID : 24449914


Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.


Le Rouzic EBonnard DChasset SBruneau JMChevreuil FLe Strat FNguyen JBeauvoir RAmadori CBrias JVomscheid SEiler SLevy NDelelis O,Deprez ESaïb AZamborlini AEmiliani SRuff MLedoussal BMoreau FBenarous R.

Retrovirology (2013) Nov 21;10:144

PMID : 24261564  



Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.


Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M

EMBO J. (2009);28(7):980-9


Transportin-SR2 imports HIV into the nucleus.


Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z

Curr Biol. (2008);18(16):1192-202


Von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.


Mousnier A, Kubat N, Massias-Simon A, Ségéral E, Rain JC, Benarous R, Emiliani S, Dargemont C.

Proc Nat Acad Sc USA. (2007);104(34):13615-20



HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.


Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J., Rasaiyaah, J. and Fassati, A.

Retrovirology. (2009) 6:11.


Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.


Loh, B., Vozzolo, L., Mok, B.J., Lee, C.C., Fitzmaurice, R.J., Caddick, S., Fassati, A

Chem Biol Drug Des. (2010).75:461-74


A gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.


Vozzolo, L., Loh, B., Gane, P.J., Tribak, M., Nyakatura, E., and Fassati, A.

J. Biol. Chem. (2010). 285: 39314-28.


Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. 


Zhou, L., Sokolskaja, E., Jolly, C., James, W., Cowley, S.A., Fassati, A.

PLoS Pathog. (2011). 7(8):e1002194
PMID: 21901095


The structural biology of HIV-1: mechanistic and therapeutic insights.


Engelman, A. and Cherepanov, P. 

Nature Reviews Microbiology, (2012)in press;
PMID: 22421880


Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)


Hare, S., Smith, S.J., Metifiot, M., Jaxa-Chamiec, A., Pommier, Y., Hughes, S.H. and Cherepanov, P

Mol. Pharmacol.(2011), 80, 565-572


Structural insights into the retroviral DNA integration apparatus


Cherepanov, P., Maertens, G. and Hare, S

Curr. Opin. Struct. Biol. (2011), 21, 249-256

PMID : 21277766


Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import


Cribier A, Segeral E, Delelis O, Parissi V, Simon A, Ruff M, Benarous R, Emiliani S

Retrovirology. (2011) 8:104.

PMID : 22176773


SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx


Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M

Nature (2011). 474:654-7

PMID : 21613998


Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.


Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Koh Y, Magne F, Giron ML, Tobaly-Tapiero J, Deprez E, Emiliani S, Engelman A, de Thé H, Saïb A

J Biol Chem. (2011). 286:21013

PMID : 21454548



Directed HIV-1 evolution of protease inhibitor resistance by 2nd generation short hairpin RNAs.


Schopman NC et al.

Antimicrobial Agents and Chemotherapy. (2012) 56:479-86

PMID : 22064528


Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors.


Eekels JJ et al. 

Antiviral Research. (2011) 89:43-53

PMID : 21093490210


Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.


Centlivre M et al.

Gene Therapy. (2010) 17:14-25.

PMID :  19727135