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23-07-2015HIVinnov will co-organise a satelite symposium at the 15th EACS (European AIDS Clinical Society) European AIDS conference in Barcelona on October 20th 2015.
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16-07-2015This study published by Prof. Miles Davenport from the university of New Wales (Australia) in PLOS Pathogens provides new insights on the frequency of activation among latently...
HIVINNOV (Grant n°305137) is a collaborative research project supported by the European Union
Publications
Heat shock protein 90 controls HIV-1 reactivation from latency
Anderson I, Low JS, Weston S, Weinberger M, Zhyvoloup A, Labokha AA, Corazza G, Kitson RA, Moody CJ, Marcello A, Fassati A.
PNAS (2014) Apr 15;111(15):E1528-37
Structural basis for nuclear import of splicing factors by human Transportin 3
Goedele N. Maertens, Nicola J. Cook, Weifeng Wang, Stephen Hare, Saumya Shree Gupta, Ilker Öztop,KyeongEun Lee, Valerie E. Pye, Ophélie Cosnefroy, Ambrosius P. Snijders, Vineet N. KewalRamani, Ariberto Fassati, Alan Engelman and Peter Cherepanov
PNAS 2014 Feb 18;111(7):2728-33
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Levy N, Delelis O,Deprez E, Saïb A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R.
Retrovirology (2013) Nov 21;10:144
Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.
Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M
EMBO J. (2009);28(7):980-9
PMID:19229293
Transportin-SR2 imports HIV into the nucleus.
Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z
Curr Biol. (2008);18(16):1192-202
PMID:18722123
Von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.
Mousnier A, Kubat N, Massias-Simon A, Ségéral E, Rain JC, Benarous R, Emiliani S, Dargemont C.
Proc Nat Acad Sc USA. (2007);104(34):13615-20
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.
Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J., Rasaiyaah, J. and Fassati, A.
Retrovirology. (2009) 6:11.
PMID:19193229
Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.
Loh, B., Vozzolo, L., Mok, B.J., Lee, C.C., Fitzmaurice, R.J., Caddick, S., Fassati, A
Chem Biol Drug Des. (2010).75:461-74
PMID:20486932
A gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.
Vozzolo, L., Loh, B., Gane, P.J., Tribak, M., Nyakatura, E., and Fassati, A.
J. Biol. Chem. (2010). 285: 39314-28.
PMID:20937817
Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.
Zhou, L., Sokolskaja, E., Jolly, C., James, W., Cowley, S.A., Fassati, A.
PLoS Pathog. (2011). 7(8):e1002194
PMID: 21901095
The structural biology of HIV-1: mechanistic and therapeutic insights.
Engelman, A. and Cherepanov, P.
Nature Reviews Microbiology, (2012)in press;
PMID: 22421880
Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)
Hare, S., Smith, S.J., Metifiot, M., Jaxa-Chamiec, A., Pommier, Y., Hughes, S.H. and Cherepanov, P
Mol. Pharmacol.(2011), 80, 565-572
Structural insights into the retroviral DNA integration apparatus
Cherepanov, P., Maertens, G. and Hare, S
Curr. Opin. Struct. Biol. (2011), 21, 249-256
Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import
Cribier A, Segeral E, Delelis O, Parissi V, Simon A, Ruff M, Benarous R, Emiliani S
Retrovirology. (2011) 8:104.
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M
Nature (2011). 474:654-7
Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.
Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Koh Y, Magne F, Giron ML, Tobaly-Tapiero J, Deprez E, Emiliani S, Engelman A, de Thé H, Saïb A
J Biol Chem. (2011). 286:21013
Directed HIV-1 evolution of protease inhibitor resistance by 2nd generation short hairpin RNAs.
Schopman NC et al.
Antimicrobial Agents and Chemotherapy. (2012) 56:479-86
Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors.
Eekels JJ et al.
Antiviral Research. (2011) 89:43-53
Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.
Centlivre M et al.
Gene Therapy. (2010) 17:14-25.