News & Events

Extranet


FP7
HIVINNOV (Grant n°305137) is a collaborative research project supported by the European Union


Publications

 

Heat shock protein 90 controls HIV-1 reactivation from latency

 

Anderson I, Low JS, Weston S, Weinberger M, Zhyvoloup A, Labokha AA, Corazza G, Kitson RA, Moody CJ, Marcello A, Fassati A.

PNAS (2014) Apr 15;111(15):E1528-37

PMID : 24706778

 

Structural basis for nuclear import of splicing factors by human Transportin 3

 

Goedele N. Maertens, Nicola J. Cook, Weifeng Wang, Stephen Hare, Saumya Shree Gupta, Ilker Öztop,KyeongEun Lee, Valerie E. Pye, Ophélie Cosnefroy, Ambrosius P. Snijders, Vineet N. KewalRamani, Ariberto Fassati, Alan Engelman and Peter Cherepanov

PNAS 2014 Feb 18;111(7):2728-33

PMID : 24449914

 

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.

 

Le Rouzic EBonnard DChasset SBruneau JMChevreuil FLe Strat FNguyen JBeauvoir RAmadori CBrias JVomscheid SEiler SLevy NDelelis O,Deprez ESaïb AZamborlini AEmiliani SRuff MLedoussal BMoreau FBenarous R.

Retrovirology (2013) Nov 21;10:144

PMID : 24261564  

 

 

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.

 

Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M

EMBO J. (2009);28(7):980-9
PMID:19229293

 

Transportin-SR2 imports HIV into the nucleus.

 

Christ F, Thys W, De Rijck J, Gijsbers R, Albanese A, Arosio D, Emiliani S, Rain JC, Benarous R, Cereseto A, Debyser Z

Curr Biol. (2008);18(16):1192-202
PMID:18722123

 

Von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.

 

Mousnier A, Kubat N, Massias-Simon A, Ségéral E, Rain JC, Benarous R, Emiliani S, Dargemont C.

Proc Nat Acad Sc USA. (2007);104(34):13615-20

PMID:17698809

 

HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.

 

Zaitseva, L., Cherepanov, P., Leyens, L., Wilson, S.J., Rasaiyaah, J. and Fassati, A.

Retrovirology. (2009) 6:11.
PMID:19193229

 

Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides.

 

Loh, B., Vozzolo, L., Mok, B.J., Lee, C.C., Fitzmaurice, R.J., Caddick, S., Fassati, A

Chem Biol Drug Des. (2010).75:461-74
PMID:20486932

 

A gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein.

 

Vozzolo, L., Loh, B., Gane, P.J., Tribak, M., Nyakatura, E., and Fassati, A.

J. Biol. Chem. (2010). 285: 39314-28.
PMID:20937817

 

Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration. 

 

Zhou, L., Sokolskaja, E., Jolly, C., James, W., Cowley, S.A., Fassati, A.

PLoS Pathog. (2011). 7(8):e1002194
PMID: 21901095

 

The structural biology of HIV-1: mechanistic and therapeutic insights.

 

Engelman, A. and Cherepanov, P. 

Nature Reviews Microbiology, (2012)in press;
PMID: 22421880

  

Structural and Functional Analyses of the Second-generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

 

Hare, S., Smith, S.J., Metifiot, M., Jaxa-Chamiec, A., Pommier, Y., Hughes, S.H. and Cherepanov, P

Mol. Pharmacol.(2011), 80, 565-572

 

Structural insights into the retroviral DNA integration apparatus

 

Cherepanov, P., Maertens, G. and Hare, S

Curr. Opin. Struct. Biol. (2011), 21, 249-256

PMID : 21277766

 

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import

 

Cribier A, Segeral E, Delelis O, Parissi V, Simon A, Ruff M, Benarous R, Emiliani S

Retrovirology. (2011) 8:104.

PMID : 22176773

 

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

 

Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Ségéral E, Yatim A, Emiliani S, Schwartz O, Benkirane M

Nature (2011). 474:654-7

PMID : 21613998

 

Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.

 

Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Koh Y, Magne F, Giron ML, Tobaly-Tapiero J, Deprez E, Emiliani S, Engelman A, de Thé H, Saïb A

J Biol Chem. (2011). 286:21013

PMID : 21454548

 

 

Directed HIV-1 evolution of protease inhibitor resistance by 2nd generation short hairpin RNAs.

 

Schopman NC et al.

Antimicrobial Agents and Chemotherapy. (2012) 56:479-86

PMID : 22064528

 

Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors.

 

Eekels JJ et al. 

Antiviral Research. (2011) 89:43-53

PMID : 21093490210

 

Autoregulatory lentiviral vectors allow multiple cycles of doxycycline-inducible gene expression in human hematopoietic cells in vivo.

 

Centlivre M et al.

Gene Therapy. (2010) 17:14-25.

PMID :  19727135